LBR and MECP2

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		LBR	MECP2
Description		lamin B receptor	methyl-CpG binding protein 2
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Heterochromatin Extracellular Space Nucleus Nucleoplasm Centrosome Cytosol Postsynapse
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Protein N-terminus Binding Promoter-specific Chromatin Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription Initiation From RNA Polymerase II Promoter Glutamine Metabolic Process Cellular Biogenic Amine Metabolic Process Mitotic Spindle Organization Synapse Assembly Respiratory Gaseous Exchange By Respiratory System Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Visual Learning Post-embryonic Development Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Dendrite Development Negative Regulation Of Angiogenesis Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Cardiolipin Metabolic Process Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Microtubule Nucleation Positive Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of DNA Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways		Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity
Drugs
Diseases		HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	Non-syndromic X-linked mental retardation Rett syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Delirium ( 29631748) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 26663301 26502338 19838195)
Interacting Genes		12 interacting genes: AKAP8L CBX3 CBX5 CD81 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG	19 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HDAC1 HIPK2 HMGB1 LBR NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1
Entrez ID		3930	4204
HPRD ID		02488	02050
Ensembl ID		ENSG00000143815	ENSG00000169057
Uniprot IDs		Q14739	A0A140VKC4 D3YJ43 P51608 Q59FJ6
PDB IDs		2DIG	1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK
Enriched GO Terms of Interacting Partners?
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