AZI2 and TICAM1

Data Source:
HPRD (in vivo)

		AZI2	TICAM1
Description		5-azacytidine induced 2	toll like receptor adaptor molecule 1
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GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Autophagosome Cytosol Endosome Membrane Ripoptosome
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle I-kappaB Kinase/NF-kappaB Signaling Viral Process T Cell Activation Dendritic Cell Proliferation Dendritic Cell Differentiation	Macrophage Activation Involved In Immune Response Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Viral Process Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways			Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323)	Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757 22561518)
Interacting Genes		13 interacting genes: APBA3 FAM107A IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA	24 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1
Entrez ID		64343	148022
HPRD ID		10577	06350
Ensembl ID		ENSG00000163512	ENSG00000127666
Uniprot IDs		Q9H6S1	Q8IUC6
PDB IDs		5EP6 5Z7G 5Z7L	2M1X 2M63 3RC4 4BSX 4C0M 5JEL
Enriched GO Terms of Interacting Partners?
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