SRSF6 and TOE1

Data Source:
BioGRID (two hybrid)

		SRSF6	TOE1
Description		serine and arginine rich splicing factor 6	target of EGR1, exonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding SnRNA Binding Metal Ion Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Splice Site Selection RNA Export From Nucleus MRNA Export From Nucleus Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Response To Insulin Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	SnRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Adult body size ( 32376654) Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		16 interacting genes: APP CLK1 LUC7L LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRPK2 SRSF4 TERF1 TERF2 TOE1 TRA2B	25 interacting genes: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		6431	114034
HPRD ID		09054	18212
Ensembl ID		ENSG00000124193	ENSG00000132773
Uniprot IDs		Q13247	Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?
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