ARHGEF28 and YWHAH

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARHGEF28	YWHAH
Description		Rho guanine nucleotide exchange factor 28	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Cell Morphogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		EPHB-mediated forward signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Chin dimples ( 27182965) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol ( 30275531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		6 interacting genes: CTAG1A CTAG1B MAPK8IP1 RHOA YWHAE YWHAH	66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		64283	7533
HPRD ID		15244	00215
Ensembl ID		ENSG00000214944	ENSG00000128245
Uniprot IDs		Q8N1W1	A0A024R1K7 Q04917 Q9H4N8
PDB IDs		6BC0 6BC1	2C63 2C74
Enriched GO Terms of Interacting Partners?
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