SRSF3 and PCBP2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SRSF3	PCBP2
Description		serine and arginine rich splicing factor 3	poly(rC) binding protein 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Postsynaptic Density Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Phospholipase Binding Sequence-specific MRNA Binding	Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding C-rich Single-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Leukemia Inhibitory Factor	MRNA Splicing, Via Spliceosome Regulation Of Gene Expression RNA Metabolic Process MRNA Metabolic Process Negative Regulation Of Type I Interferon Production Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Defense Response To Virus Regulation Of RNA Metabolic Process Defense Response To Virus IRES-dependent Viral Translational Initiation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		39 interacting genes: APP CHD1 CIRBP CLK1 CLK2 CLK3 CNNM3 DUX4 EXOSC6 GEMIN2 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMX RBMY1A1 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF1L5 U2AF2 YWHAB YWHAG YWHAQ	28 interacting genes: BARD1 CASK CNBP FLNA FTH1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL LINC01554 NKAP PABPC1 PAXIP1 PCBP1 PRPF40A PTBP1 QKI SF3B2 SLU7 SNRPA SRSF3 SRSF7 UBC WDR77 WDR83 YBX1 YBX3
Entrez ID		6428	5094
HPRD ID		04530	03129
Ensembl ID		ENSG00000112081	ENSG00000197111
Uniprot IDs		B2R6F3 P84103	A0A384N6B9 Q15366
PDB IDs		2I2Y 2I38	2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?
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