TRIB1 and MAP2K7

Data Source:
HPRD (in vivo)

		TRIB1	MAP2K7
Description		tribbles pseudokinase 1	mitogen-activated protein kinase kinase 7
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JNK Cascade Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Activation Of MAPK Activity Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Telomere Capping
Pathways		NGF-stimulated transcription	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Adult body size ( 32376654) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol ( 31902109) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Fractures (paediatric) ( 32742401) Gamma glutamyl transferase levels ( 29403010) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068 25961943 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hypertriglyceridemia ( 27599772) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 24097068 20864672 19060911 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095) Liver enzyme levels (alanine transaminase) ( 22001757) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Microalbuminuria ( 31511532) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Nonalcoholic fatty liver disease ( 31311600) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Rosacea symptom severity ( 29771307) Serum alkaline phosphatase levels ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 29403010) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 29403010) Triglyceride levels ( 32203549 28334899 31647587 30911093 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 24886709 20139978 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 32499647) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count (basophil) ( 29403010)	HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		8 interacting genes: ALOX12 CEBPB CEBPD CEBPE COP1 MAP2K1 MAP2K4 MAP2K7	32 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		10221	5609
HPRD ID		09863	04309
Ensembl ID		ENSG00000173334	ENSG00000076984
Uniprot IDs		Q96RU8	B4DV95 O14733
PDB IDs		5CEK 5CEM 5IGO 5IGQ 6DC0	2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX
Enriched GO Terms of Interacting Partners?
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