IFIH1 and USP3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		IFIH1	USP3
Description		interferon induced with helicase C domain 1	ubiquitin specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule Flemming Body
	Molecular Function	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Ribonucleoprotein Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone Binding Promoter-specific Chromatin Binding
	Biological Process	Detection Of Virus Response To Virus Viral Process Protein Deubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Repair Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Ub-specific processing proteases
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260 30572963) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)	Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Heart failure ( 20445134) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) LDL cholesterol levels ( 32203549) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum immune biomarker levels ( 32066700) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		6 interacting genes: APP KEAP1 TRIM40 TRIM65 USP3 ZCCHC3	6 interacting genes: CHEK1 DDX58 IFIH1 SNAI1 TP53 UBC
Entrez ID		64135	9960
HPRD ID		09507	05290
Ensembl ID		ENSG00000115267	ENSG00000140455
Uniprot IDs		Q9BYX4	Q6JHV3 Q9Y6I4
PDB IDs		2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?
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