IFIH1 and TRIM40

Data Source:
BioGRID (enzymatic study)

		IFIH1	TRIM40
Description		interferon induced with helicase C domain 1	tripartite motif containing 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm IkappaB Kinase Complex
	Molecular Function	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Ribonucleoprotein Complex Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Detection Of Virus Response To Virus Viral Process Protein Deubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Innate Immune Response Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260 30572963) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)	Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494 27863252) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: APP KEAP1 TRIM40 TRIM65 USP3 ZCCHC3	3 interacting genes: APP DDX58 IFIH1
Entrez ID		64135	135644
HPRD ID		09507	15557
Ensembl ID		ENSG00000115267	ENSG00000204614
Uniprot IDs		Q9BYX4	A0A1U9X8U1 Q6P9F5
PDB IDs		2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?
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