SEMG1 and KLK2

Data Source:
HPRD (in vitro)

		SEMG1	KLK2
Description		semenogelin 1	kallikrein related peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Serine-type Endopeptidase Activity
	Biological Process	Insemination Antimicrobial Humoral Response Antibacterial Humoral Response Killing Of Cells Of Other Organism Cellular Protein Metabolic Process Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Antimicrobial peptides Amyloid fiber formation	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Malaria ( 31844061)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		9 interacting genes: EAF1 KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN2 UBQLN4	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		6406	3817
HPRD ID		01641	01006
Ensembl ID		ENSG00000124233	ENSG00000167751
Uniprot IDs		P04279	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs			4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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