SEL1L and HYOU1

Data Source:
BioGRID (pull down)

		SEL1L	HYOU1
Description		SEL1L adaptor subunit of ERAD E3 ubiquitin ligase	hypoxia up-regulated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Triglyceride Metabolic Process Notch Signaling Pathway Protein Secretion Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol ERAD Pathway Protein Stabilization Transmembrane Transport Endoplasmic Reticulum Mannose Trimming	Response To Ischemia Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Regulation Of Catalytic Activity Cellular Response To Hypoxia Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Processing in Golgi ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Cadmium levels ( 26025379) Intraocular pressure ( 29617998) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)	Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		2 interacting genes: HYOU1 RPL6	3 interacting genes: CDC42 LINC01554 SEL1L
Entrez ID		6400	10525
HPRD ID		07532	03448
Ensembl ID		ENSG00000071537	ENSG00000149428
Uniprot IDs		Q3ZCU6 Q9UBV2	A0A384P5T6 A0A494C039 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1
PDB IDs
Enriched GO Terms of Interacting Partners?
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