HYOU1 and SEL1L

Data Source:
BioGRID (pull down)

		HYOU1	SEL1L
Description		hypoxia up-regulated 1	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Chaperone Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Response To Ischemia Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Regulation Of Catalytic Activity Cellular Response To Hypoxia Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway	Triglyceride Metabolic Process Notch Signaling Pathway Protein Secretion Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol ERAD Pathway Protein Stabilization Transmembrane Transport Endoplasmic Reticulum Mannose Trimming
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes	Pre-NOTCH Processing in Golgi ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Body size at age 10 ( 32376654) Cadmium levels ( 26025379) Intraocular pressure ( 29617998) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		3 interacting genes: CDC42 LINC01554 SEL1L	2 interacting genes: HYOU1 RPL6
Entrez ID		10525	6400
HPRD ID		03448	07532
Ensembl ID		ENSG00000149428	ENSG00000071537
Uniprot IDs		A0A384P5T6 A0A494C039 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	Q3ZCU6 Q9UBV2
PDB IDs
Enriched GO Terms of Interacting Partners?
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