CHP2 and SLC9A1

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro)

		CHP2	SLC9A1
Description		calcineurin like EF-hand protein 2	solute carrier family 9 member A1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Solute:proton Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Calcium-dependent Protein Binding Molecular Adaptor Activity Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
	Biological Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatase Activity Protein Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion	Ion Transport Cellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Sensory Perception Of Pain Cardiac Muscle Cell Differentiation Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Neuron Death Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Proton Transmembrane Transport Positive Regulation Of Calcium:sodium Antiporter Activity
Pathways			Hyaluronan uptake and degradation Sodium/Proton exchangers
Drugs			Amiloride Homoserine Lactone Cariporide
Diseases
GWAS			Lateral ventricle volume ( 31530798)
Interacting Genes		6 interacting genes: MDFI SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5	12 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI TESC WNK1 YWHAB
Entrez ID		63928	6548
HPRD ID		14259	00123
Ensembl ID		ENSG00000166869	ENSG00000090020
Uniprot IDs		O43745	B2RAH2 P19634
PDB IDs		2BEC	1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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