SLC9A1 and CA2

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		SLC9A1	CA2
Description		solute carrier family 9 member A1	carbonic anhydrase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex	Cytoplasm Cytosol Plasma Membrane Microvillus Basolateral Plasma Membrane Axon Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Solute:proton Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Calcium-dependent Protein Binding Molecular Adaptor Activity Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Arylesterase Activity Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Ion Transport Cellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Sensory Perception Of Pain Cardiac Muscle Cell Differentiation Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Neuron Death Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Proton Transmembrane Transport Positive Regulation Of Calcium:sodium Antiporter Activity	Kidney Development One-carbon Metabolic Process Response To PH Response To Zinc Ion Carbon Dioxide Transport Bicarbonate Transport Positive Regulation Of Cellular PH Reduction Angiotensin-activated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Response To Estrogen Regulation Of Anion Transport Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Response To Steroid Hormone Regulation Of Intracellular PH Cellular Response To Fluid Shear Stress Positive Regulation Of Dipeptide Transmembrane Transport
Pathways		Hyaluronan uptake and degradation Sodium/Proton exchangers	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		Amiloride Homoserine Lactone Cariporide	Methyclothiazide Topiramate Ethoxzolamide Sulpiride Bendroflumethiazide Celecoxib Benzthiazide Benzthiazide Valdecoxib Cyclothiazide Cyclothiazide Furosemide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Trichlormethiazide Ethinamate Diazoxide Diclofenamide Brinzolamide Quinethazone p-Hydroxymercuribenzoic acid N-Benzyl-4-Sulfamoyl-Benzamide 4-Flourobenzenesulfonamide Formic acid AL5424 N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide 3,5-Difluorobenzenesulfonamide AL7089A 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide Irosustat 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide AL7182 N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide Cyanamide 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide Dansylamide Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide AL7099A Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide] 2,6-Difluorobenzenesulfonamide 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester 4-Methylimidazole AL5927 1,2,4-Triazole N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide] 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide AL-4623 Urea (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide Mercuribenzoic Acid 4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide AL5300 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide 3-Mercuri-4-Aminobenzenesulfonamide AL6528 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE) (S)-Indapamide N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE indane-5-sulfonamide 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE Sulthiame (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE 4-(2-AMINOETHYL)BENZENESULFONAMIDE Ellagic acid Sodium carbonate Sodium sulfate
Diseases			Combined proximal and distal renal tubular acidosis (RTA type 3) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Lateral ventricle volume ( 31530798)	Blood trace element (Zn levels) ( 23720494)
Interacting Genes		12 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI TESC WNK1 YWHAB	11 interacting genes: ANKZF1 DISP3 DYNLL1 HSPD1 NONO SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A8 SLC9A1
Entrez ID		6548	760
HPRD ID		00123	02023
Ensembl ID		ENSG00000090020	ENSG00000104267
Uniprot IDs		B2RAH2 P19634	P00918 V9HW21
PDB IDs		1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU	12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL 1CAM 1CAN 1CAO 1CAY 1CAZ 1CCS 1CCT 1CCU 1CIL 1CIM 1CIN 1CNB 1CNC 1CNG 1CNH 1CNI 1CNJ 1CNK 1CNW 1CNX 1CNY 1CRA 1CVA 1CVB 1CVC 1CVD 1CVE 1CVF 1CVH 1DCA 1DCB 1EOU 1F2W 1FQL 1FQM 1FQN 1FQR 1FR4 1FR7 1FSN 1FSQ 1FSR 1G0E 1G0F 1G1D 1G3Z 1G45 1G46 1G48 1G4J 1G4O 1G52 1G53 1G54 1H4N 1H9N 1H9Q 1HCA 1HEA 1HEB 1HEC 1HED 1HVA 1I8Z 1I90 1I91 1I9L 1I9M 1I9N 1I9O 1I9P 1I9Q 1IF4 1IF5 1IF6 1IF7 1IF8 1IF9 1KWQ 1KWR 1LG5 1LG6 1LGD 1LUG 1LZV 1MOO 1MUA 1OKL 1OKM 1OKN 1OQ5 1RAY 1RAZ 1RZA 1RZB 1RZC 1RZD 1RZE 1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9 1THK 1TTM 1UGA 1UGB 1UGC 1UGD 1UGE 1UGF 1UGG 1XEG 1XEV 1XPZ 1XQ0 1YDA 1YDB 1YDC 1YDD 1YO0 1YO1 1YO2 1Z9Y 1ZE8 1ZFK 1ZFQ 1ZGE 1ZGF 1ZH9 1ZSA 1ZSB 1ZSC 2ABE 2AW1 2AX2 2CA2 2CBA 2CBB 2CBC 2CBD 2CBE 2EU2 2EU3 2EZ7 2F14 2FMG 2FMZ 2FNK 2FNM 2FNN 2FOQ 2FOS 2FOU 2FOV 2GD8 2GEH 2H15 2H4N 2HD6 2HKK 2HL4 2HNC 2HOC 2ILI 2NNG 2NNO 2NNS 2NNV 2NWO 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT 2O4Z 2OSF 2OSM 2POU 2POV 2POW 2Q1B 2Q1Q 2Q38 2QO8 2QOA 2QP6 2VVA 2VVB 2WD2 2WD3 2WEG 2WEH 2WEJ 2WEO 2X7S 2X7T 2X7U 3B4F 3BET 3BL0 3BL1 3C7P 3CA2 3CAJ 3CYU 3D8W 3D92 3D93 3D9Z 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 3DD8 3DV7 3DVB 3DVC 3DVD 3EFI 3EFT 3F4X 3F8E 3FFP 3GZ0 3HFP 3HKN 3HKQ 3HKT 3HKU 3HLJ 3HS4 3IBI 3IBL 3IBN 3IBU 3IEO 3IGP 3K2F 3K34 3K7K 3KIG 3KKX 3KNE 3KOI 3KOK 3KON 3KS3 3KWA 3L14 3M04 3M14 3M1J 3M1K 3M1Q 3M1W 3M2N 3M2X 3M2Y 3M2Z 3M3X 3M40 3M5E 3M5S 3M5T 3M67 3M96 3M98 3MHC 3MHI 3MHL 3MHM 3MHO 3ML2 3MMF 3MNA 3MNH 3MNI 3MNJ 3MNK 3MNU 3MWO 3MYQ 3MZC 3N0N 3N2P 3N3J 3N4B 3NB5 3NI5 3NJ9 3OIK 3OIL 3OIM 3OKU 3OKV 3OY0 3OYQ 3OYS 3P3H 3P3J 3P44 3P4V 3P55 3P58 3P5A 3P5L 3PJJ 3PO6 3PYK 3QYK 3R16 3R17 3RG3 3RG4 3RGE 3RJ7 3RLD 3RYJ 3RYV 3RYX 3RYY 3RYZ 3RZ0 3RZ1 3RZ5 3RZ7 3RZ8 3S71 3S72 3S73 3S74 3S75 3S76 3S77 3S78 3S8X 3S9T 3SAP 3SAX 3SBH 3SBI 3T5U 3T5Z 3T82 3T83 3T84 3T85 3TMJ 3TVN 3TVO 3U3A 3U45 3U47 3U7C 3V2J 3V2M 3V3F 3V3G 3V3H 3V3I 3V3J 3V5G 3V7X 3VBD 3ZP9 4BCW 4BF1 4BF6 4CA2 4CAC 4CQ0 4DZ7 4DZ9 4E3D 4E3F 4E3G 4E3H 4E49 4E4A 4E5Q 4FIK 4FL7 4FPT 4FRC 4FU5 4FVN 4FVO 4G0C 4GL1 4HBA 4HEW 4HEY 4HEZ 4HF3 4HT0 4IDR 4ILX 4ITO 4ITP 4IWZ 4JS6 4JSA 4JSS 4JSW 4JSZ 4K0S 4K0T 4K0Z 4K13 4K1Q 4KAP 4KNI 4KNJ 4KUV 4KUW 4KUY 4KV0 4L5U 4L5V 4L5W 4LHI 4LP6 4M2R 4M2U 4M2V 4M2W 4MDG 4MDL 4MDM 4MLT 4MLX 4MO8 4MTY 4N0X 4N16 4PQ7 4PXX 4PYX 4PYY 4PZH 4Q06 4Q07 4Q08 4Q09 4Q49 4Q6D 4Q6E 4Q78 4Q7P 4Q7S 4Q7V 4Q7W 4Q81 4Q83 4Q87 4Q8X 4Q8Y 4Q8Z 4Q90 4Q99 4Q9Y 4QEF 4QIY 4QJM 4QK1 4QK2 4QK3 4QSA 4QSB 4QSI 4QTL 4QY3 4R59 4R5A 4R5B 4RFC 4RFD 4RH2 4RIU 4RIV 4RN4 4RUX 4RUY 4RUZ 4WL4 4WW6 4XE1 4Y0J 4YGJ 4YGK 4YGL 4YGN 4YVY 4YWP 4YX4 4YXI 4YXO 4YXU 4YYT 4Z0Q 4Z1E 4Z1J 4Z1K 4Z1N 4ZAO 4ZWI 4ZWX 4ZWY 4ZWZ 4ZX0 4ZX1 5A6H 5AMD 5AMG 5AML 5BNL 5BRU 5BRV 5BRW 5BYI 5C8I 5CA2 5CAC 5CLU 5DOG 5DOH 5DRS 5DSK 5DSL 5DSM 5DSO 5DSP 5DSQ 5DSR 5E28 5E2K 5E2R 5E2S 5EH5 5EH7 5EH8 5EHE 5EHV 5EHW 5EIJ 5EKH 5EKJ 5EKM 5EOI 5FDC 5FDI 5FLO 5FLP 5FLQ 5FLR 5FLS 5FLT 5FNG 5FNH 5FNI 5FNJ 5FNK 5FNL 5FNM 5G01 5G03 5G0B 5G0C 5GMN 5J8Z 5JDV 5JE7 5JEG 5JEH 5JEP 5JES 5JG3 5JG5 5JGS 5JGT 5JMZ 5JN3 5JN7 5JQ0 5JQT 5L3O 5L6K 5L6T 5L70 5L9E 5LJQ 5LJT 5LL4 5LL8 5LLC 5LLE 5LLG 5LLH 5LMD 5LVS 5M78 5MJN 5N0D 5N0E 5N1R 5N1S 5N24 5N25 5NEA 5NEE 5NXG 5NXI 5NXM 5NXO 5NXP 5NXV 5NXW 5NY1 5NY3 5NY6 5NYA 5O07 5OGN 5OGO 5OGP 5SZ0 5SZ1 5SZ2 5SZ3 5SZ4 5SZ5 5SZ6 5SZ7 5T71 5T72 5T74 5T75 5TFX 5TH4 5THI 5THJ 5THN 5TI0 5TXY 5TY1 5TY8 5TY9 5TYA 5U0D 5U0E 5U0F 5U0G 5ULN 5UMC 5VGY 5W8B 5WEX 5WG7 5WGP 5WLR 5WLT 5WLU 5WLV 5Y2R 5Y2S 5YUI 5YUJ 5YUK 5ZXW 6B4D 6B59 6B5A 6BBS 6BC9 6BCC 6C7W 6C7X 6CA2 6CEH 6CJV 6D1L 6D1M 6E8P 6E8X 6E91 6E92 6EBE 6ECZ 6EDA 6EEA 6EEH 6EEO 6EQU 6FJI 6FJJ 6G3Q 6G6T 6GCY 6GDC 6GM9 6GOT 6GXB 6GXE 6H29 6H2Z 6H33 6H34 6H3Q 6H6S 6HD2 6HQX 6HR3 6HX5 6HXD 6HZX 6I0W 6I1U 6I2F 6I3E 6IC2 6KLZ 6KM0 6KM1 6KM2 6KM3 6KM4 6KM5 6KM6 6LUU 6LUV 6LUW 6LUX 6LUY 6LUZ 6LV1 6LV2 6LV3 6LV4 6LV5 6LV6 6LV7 6LV8 6LV9 6LVA 6MBV 6MBY 6NLV 6NM0 6ODZ 6OE0 6OE1 6OTI 6OTK 6OTM 6OTO 6OTP 6OTQ 6OUB 6OUD 6OUE 6OUF 6OUH 6OUI 6OUJ 6OUK 6OUM 6PDV 6PEA 6PGX 6Q3O 6Q9T 6QEB 6QL1 6QL2 6QL3 6R6F 6R6J 6RFH 6RG3 6RG4 6RG5 6RH4 6RHJ 6RHK 6RIG 6RIT 6RJJ 6RKN 6RL9 6RM1 6RMP 6RMX 6RMY 6RNP 6ROB 6ROE 6ROF 6RQI 6RRG 6RRI 6RS5 6RSZ 6RVF 6RVK 6RVL 6RW1 6RZX 6S03 6S9G 6S9Z 6SAC 6SAS 6SAY 6SB7 6SBH 6SBL 6SBM 6SD7 6SDH 6SDI 6SDJ 6SDL 6SDS 6SEY 6SFQ 6SFU 6SG0 6SG6 6SX9 6SYB 6SYS 6T4N 6T4O 6T4P 6T5C 6T7U 6T81 6T9Z 6U4Q 6U4T 6UFB 6UFC 6UFD 6UGN 6UGO 6UGP 6UGQ 6UGR 6UGZ 6UH0 6UX1 6UZU 6VJ3 6VKG 6WQ4 6WQ5 6WQ7 6WQ8 6WQ9 6XXT 6YJ3 6YKC 6YKH 6YMA 6YMB 6YO2 6YO4 6YO7 6YOI 6YOK 6YOL 6YQT 6YQU 6YZJ 6YZK 6YZL 6YZM 6YZN 6YZO 6YZP 6YZQ 6YZR 6YZS 6YZT 6YZU 6YZV 6YZW 6YZX 6Z04 7CA2 7JNR 7JNV 7JNW 7JNX 7JNZ 7JO0 7JO1 7JO2 7JO3 7JOB 7JOC 8CA2 9CA2
Enriched GO Terms of Interacting Partners?
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