CX3CL1 and CX3CR1

Data Source:
HPRD (in vitro, in vivo)

		CX3CL1	CX3CR1
Description		C-X3-C motif chemokine ligand 1	C-X3-C motif chemokine receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cell Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding Chemokine Activity CX3C Chemokine Receptor Binding Chemoattractant Activity CXCR1 Chemokine Receptor Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Response To Ischemia Chemotaxis Defense Response Inflammatory Response Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Neuron Remodeling Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Neutrophil Chemotaxis Leukocyte Chemotaxis Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Integrin Activation Autocrine Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Leukocyte Adhesive Activation Positive Chemotaxis Positive Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Microglial Cell Proliferation Neuron Cellular Homeostasis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Negative Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Neuroblast Proliferation Response To Ischemia Chemotaxis Immune Response Cellular Defense Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Memory Response To Wounding Viral Process Calcium-mediated Signaling Central Nervous System Maturation Negative Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Synaptic Plasticity Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Synapse Maturation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Transforming Growth Factor Beta Stimulus Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of I-kappaB Phosphorylation Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: CX3CR1	2 interacting genes: CCDC167 CX3CL1
Entrez ID		6376	1524
HPRD ID		03529	03277
Ensembl ID		ENSG00000006210	ENSG00000168329
Uniprot IDs		A0N0N7 P78423	P49238
PDB IDs		1B2T 1F2L 3ONA 4XT1 4XT3 5WB2
Enriched GO Terms of Interacting Partners?
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