CX3CL1

Description		C-X3-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cell Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding Chemokine Activity CX3C Chemokine Receptor Binding Chemoattractant Activity CXCR1 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Response To Ischemia Chemotaxis Defense Response Inflammatory Response Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Neuron Remodeling Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Neutrophil Chemotaxis Leukocyte Chemotaxis Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Integrin Activation Autocrine Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Leukocyte Adhesive Activation Positive Chemotaxis Positive Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Microglial Cell Proliferation Neuron Cellular Homeostasis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		1 interacting genes: CX3CR1
Entrez ID		6376
HPRD ID		03529
Ensembl ID		ENSG00000006210
Uniprot IDs		A0N0N7 P78423
PDB IDs		1B2T 1F2L 3ONA 4XT1 4XT3 5WB2
Enriched GO Terms of Interacting Partners?
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