CCL3 and SRGN

Data Source:
HPRD (in vivo)

		CCL3	SRGN
Description		C-C motif chemokine ligand 3	serglycin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding	Protein Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Negative Regulation Of Cytokine Production Platelet Degranulation Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling	Platelet degranulation
Drugs		ROX-888
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971)	Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)
Interacting Genes		11 interacting genes: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1 UBQLN1 UBQLN2	17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4
Entrez ID		6348	5552
HPRD ID		01656	01513
Ensembl ID		ENSG00000277632	ENSG00000122862
Uniprot IDs		A0N0R1 P10147	P10124
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65
Enriched GO Terms of Interacting Partners?
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