SCN4B and SCN2A

Data Source:
HPRD (in vivo, in vitro)

		SCN4B	SCN2A
Description		sodium voltage-gated channel beta subunit 4	sodium voltage-gated channel alpha subunit 2
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Intercalated Disc Intrinsic Component Of Plasma Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity
	Biological Process	Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil	Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Adult body size ( 32376654) Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		2 interacting genes: SCN2A YIF1A	5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		6330	6326
HPRD ID		09749	03133
Ensembl ID		ENSG00000177098	ENSG00000136531
Uniprot IDs		B0YJ93 Q8IWT1	Q99250
PDB IDs		4MZ2 4MZ3 5XAW 6VSV	2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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