SCD and CD207

Data Source:
BioGRID (two hybrid)

		SCD	CD207
Description		stearoyl-CoA desaturase	CD207 molecule
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GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Palmitoyl-CoA 9-desaturase Activity	Protein Binding Mannose Binding Carbohydrate Binding
	Biological Process	Unsaturated Fatty Acid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Monounsaturated Fatty Acid Biosynthetic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Defense Response To Virus
Pathways		Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Glycerophospholipid levels ( 26068415) Macular thickness ( 30535121) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count (basophil) ( 27863252)	Acne (severe) ( 24927181) Atopic dermatitis ( 26482879) Erythema nodosum in inflammatory bowel disease ( 24487271) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		41 interacting genes: APP AQP6 CD207 CD33 CERS4 CLEC12B CREB3L1 CYB561 CYB5A CYBC1 ERGIC3 GJB1 GPR152 GPR42 GPX8 HSD17B13 JAGN1 KCNJ6 MARCHF5 MCFD2 MFSD14B MGST3 MTIF3 NEDD4L PVR REEP2 RETREG3 RNF5 SCN3B SEC11C SLC10A6 SLC7A14 SPAG4 STOM TIMMDC1 TLCD4 TMEM30B TMPRSS2 TMX2 UBC VMA21	6 interacting genes: CREB3 ERGIC3 GRAMD2B SCD SEC22A ZCCHC12
Entrez ID		6319	50489
HPRD ID		04941	07278
Ensembl ID		ENSG00000099194	ENSG00000116031
Uniprot IDs		O00767	Q9UJ71
PDB IDs		4ZYO	3C22 3KQG 3P5D 3P5E 3P5F 3P5G 3P5H 3P5I 3P7F 3P7G 3P7H 4AK8 4N32 4N33 4N34 4N35 4N36 4N37 4N38 5G6U
Enriched GO Terms of Interacting Partners?
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