SC5D and SCN4B

Data Source:
BioGRID (pull down)

		SC5D	SCN4B
Description		sterol-C5-desaturase	sodium voltage-gated channel beta subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Voltage-gated Sodium Channel Complex Intercalated Disc Intrinsic Component Of Plasma Membrane
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Lipid Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Regulation Of Cholesterol Biosynthetic Process	Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS
Interacting Genes			2 interacting genes: SCN2A YIF1A
Entrez ID		6309	6330
HPRD ID		09078	09749
Ensembl ID		ENSG00000109929	ENSG00000177098
Uniprot IDs		A0A024R3G4 O75845	B0YJ93 Q8IWT1
PDB IDs			4MZ2 4MZ3 5XAW 6VSV
Enriched GO Terms of Interacting Partners?
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