CFB and NOMO1

Data Source:
BioGRID (proximity labelling technology)

		CFB	NOMO1
Description		complement factor B	NODAL modulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle	Cellular_component Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Complement Binding Serine-type Endopeptidase Activity Protein Binding	Molecular_function Protein Binding Carbohydrate Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation	Biological_process Negative Regulation Of Nodal Signaling Pathway
Pathways		Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs		Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate	Theophylline
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2	12 interacting genes: ATF7IP BAG6 ECT2 EXOSC10 NCLN SHBG STAT1 TOM1L1 TRIM55 TRIM63 UBQLN4 UPF2
Entrez ID		629	23420
HPRD ID		00718	11398
Ensembl ID		ENSG00000243649	ENSG00000103512
Uniprot IDs		A0A1U9X7H8 P00751	Q15155
PDB IDs		1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W
Enriched GO Terms of Interacting Partners?
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