S100A10 and PLG

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		S100A10	PLG
Description		S100 calcium binding protein A10	plasminogen
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extrinsic Component Of Plasma Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Ion Channel Binding Calcium-dependent Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding Kinase Binding Protein Domain Specific Binding Apolipoprotein Binding Chaperone Binding Protein Antigen Binding
	Biological Process	Membrane Raft Assembly Vesicle Budding From Membrane Response To Drug Positive Regulation Of GTPase Activity Positive Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Fibrinolysis Cellular Protein Metabolic Process Tissue Remodeling Biological Process Involved In Interaction With Symbiont Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Dissolution of Fibrin Clot	Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot
Drugs		Phenethyl Isothiocyanate	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic acid Aminocaproic acid Bicine Desmoteplase Aprotinin Copper Gabexate
Diseases			Inherited thrombophilia
GWAS		Asthma ( 31619474) Diverticular disease ( 30177863) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352)	Aging ( 22773346) Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood ear infection ( 27182965 28928442) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) End stage renal disease x APOL1 genotype interaction ( 29885931) Giant cell arteritis ( 28041642) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Myocardial infarction ( 26343387) Plasma plasminogen levels ( 25208887) Platelet count ( 32888494) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		21 interacting genes: ANXA2 ANXA7 BAD CDK16 COPS6 CTSB ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT	60 interacting genes: ACTB AMOT ANXA2 APOH ATP5F1B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		6281	5340
HPRD ID		00232	01417
Ensembl ID		ENSG00000197747	ENSG00000122194
Uniprot IDs		P60903	P00747 Q5TEH5
PDB IDs		1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU 5HPG 5UGD 5UGG 6D3X 6D3Y 6D3Z 6D40 6OG4 6OQJ 6OQK 6Q1U
Enriched GO Terms of Interacting Partners?
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