S100A10 and KCNK3

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, in vitro, two hybrid)

		S100A10	KCNK3
Description		S100 calcium binding protein A10	potassium two pore domain channel subfamily K member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extrinsic Component Of Plasma Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Ion Channel Binding Calcium-dependent Protein Binding	Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Protein C-terminus Binding Potassium Ion Leak Channel Activity S100 Protein Binding
	Biological Process	Membrane Raft Assembly Vesicle Budding From Membrane Response To Drug Positive Regulation Of GTPase Activity Positive Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Potassium Ion Transport Chemical Synaptic Transmission Brain Development Stabilization Of Membrane Potential Ion Transmembrane Transport Response To Drug Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Conduction Cellular Response To Zinc Ion Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development
Pathways		Dissolution of Fibrin Clot	TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential
Drugs		Phenethyl Isothiocyanate	Doxapram Halothane
Diseases
GWAS		Asthma ( 31619474) Diverticular disease ( 30177863) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352)	Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27736895 27841878 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) Hypertension ( 31879980 30487518) Ischemic stroke ( 29531354) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Potassium levels ( 29403010) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Stroke ( 29531354) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 29403010 28739976 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549)
Interacting Genes		21 interacting genes: ANXA2 ANXA7 BAD CDK16 COPS6 CTSB ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT	9 interacting genes: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6281	3777
HPRD ID		00232	04451
Ensembl ID		ENSG00000197747	ENSG00000171303
Uniprot IDs		P60903	O14649
PDB IDs		1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH	6RV2 6RV3 6RV4
Enriched GO Terms of Interacting Partners?
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