ARNTL and SIRT1

  • Data Source:
  • BioGRID (enzymatic study)

ARNTL

SIRT1

Description aryl hydrocarbon receptor nuclear translocator like sirtuin 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Body mass index ( 25673413)
  • C-reactive protein levels ( 30388399)
  • C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809)
  • Chronic obstructive pulmonary disease ( 30804561)
  • Chronotype ( 30696823)
  • Cooked vegetable consumption ( 32066663)
  • Coronary artery disease ( 32469254 29212778 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Diastolic blood pressure ( 27841878 27618448 30487518)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Face memory ( 31596458)
  • Feeling guilty ( 29500382)
  • Feeling miserable ( 29500382)
  • Fish- and plant-related diet ( 32066663)
  • General risk tolerance (MTAG) ( 30643258)
  • HDL cholesterol ( 30275531)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Iron status biomarkers (transferrin levels) ( 25352340)
  • Lipid traits (pleiotropy) (HIPO component 1) ( 30289880)
  • Mean arterial pressure ( 30487518)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Menarche (age at onset) ( 27182965 21102462 25231870)
  • Metabolic syndrome ( 31589552)
  • Neurociticism ( 29500382)
  • PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
  • Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
  • Psoriasis ( 30921485)
  • Red blood cell count ( 32888494)
  • Schizophrenia ( 23358160)
  • Systolic blood pressure ( 31928498)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Tea consumption ( 31046077)
  • Triglyceride levels ( 32203549 32154731 31928498 30698716)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Worry too long after an embarrassing experience ( 29500382)
  • Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes 25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12 63 interacting genes: AFP AKT1 AR ARNTL BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MAPT MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR
Entrez ID 406 23411
HPRD ID 03973 08381
Ensembl ID ENSG00000133794 ENSG00000096717
Uniprot IDs A0A140VKD3 A0A669KBF4 B2RCL8 O00327 A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6
PDB IDs 4H10 4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR
Enriched GO Terms of Interacting Partners?
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