RPS21 and FHL5

Data Source:
BioGRID (two hybrid)

		RPS21	FHL5
Description		ribosomal protein S21	four and a half LIM domains 5
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GO Annotations	Cellular Component	Nucleoplasm Rough Endoplasmic Reticulum Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Polysomal Ribosome	Nucleus Z Disc
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Protein N-terminus Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Colorectal cancer ( 26965516) Colorectal cancer or advanced adenoma ( 30510241) Prostate cancer ( 23535732)	Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)
Interacting Genes		8 interacting genes: APP CDC42 FHL5 LBP PLEKHF2 RPSA ZNF76 ZUP1	90 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FAM214B FAM71C FARS2 FEZF1 FHL2 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 PPP1R32 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF131 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1
Entrez ID		6227	9457
HPRD ID		01605	05497
Ensembl ID		ENSG00000171858	ENSG00000112214
Uniprot IDs		P63220 Q6FGH5	Q5TD97
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I	1X68
Enriched GO Terms of Interacting Partners?
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