RPS6KB1 and POLDIP3

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study)
HPRD (in vivo, in vitro)

		RPS6KB1	POLDIP3
Description		ribosomal protein S6 kinase B1	DNA polymerase delta interacting protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity PDZ Domain Binding Peptide Binding Identical Protein Binding Protein Phosphatase 2A Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Protein Binding Protein-containing Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Skeletal Muscle Contraction Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Long-chain Fatty Acid Import Into Cell Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Interferon-gamma Cellular Response To Growth Factor Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	RNA Export From Nucleus MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus MRNA 3'-end Processing Positive Regulation Of Translation
Pathways		mTORC1-mediated signalling	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		60 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1	28 interacting genes: BANP BICD2 CCNDBP1 ERH EXOSC8 GOLGA2 GTPBP3 HMBOX1 HOMEZ HSF2BP KRT31 KRT40 LZTS2 MID2 MTUS2 OSGIN1 OTX2 PIBF1 PNMA1 POLD2 POLR1C RAD51D RPS6KA1 RPS6KB1 SBK3 SRPK2 TEKT4 ZRANB1
Entrez ID		6198	84271
HPRD ID		10202	17875
Ensembl ID		ENSG00000108443	ENSG00000100227
Uniprot IDs		P23443	B4E0L0 F6VRR5 Q659C6 Q9BY77
PDB IDs		3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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