RPL27A and PEX6

Data Source:
BioGRID (two hybrid)

		RPL27A	PEX6
Description		ribosomal protein L27a	peroxisomal biogenesis factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Membrane Cytosolic Large Ribosomal Subunit	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Photoreceptor Cell Cilium
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein-containing Complex Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Stabilization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Body mass index ( 26426971 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Obesity ( 23563607)	Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: DUX4 GTF2F2 PEX6 PRKACB PTEN SIAH1	8 interacting genes: ATF7IP CERS2 PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Entrez ID		6157	5190
HPRD ID		04701	03293
Ensembl ID		ENSG00000166441	ENSG00000124587
Uniprot IDs		P46776	A0A024RD09 Q13608
PDB IDs		4BXF 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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