ROBO1 and SRGAP2

Data Source:
HPRD (two hybrid)

		ROBO1	SRGAP2
Description		roundabout guidance receptor 1	SLIT-ROBO Rho GTPase activating protein 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Cell Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs	Rho GTPase cycle Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Glomerular filtration rate in chronic kidney disease ( 26420894) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920)	Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: ABL1 MAGEB6 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	5 interacting genes: DISC1 EXOC1 FASLG ROBO1 YWHAG
Entrez ID		6091	23380
HPRD ID		03890	18520
Ensembl ID		ENSG00000169855	ENSG00000266028
Uniprot IDs		Q1RMC8 Q9Y6N7	A0A075B7B5 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79	2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?
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