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SRGAP2

Description SLIT-ROBO Rho GTPase activating protein 2
Image
GO Annotations Cellular Component
  • Nucleoplasm
  • Cytoplasm
  • Cytosol
  • Plasma Membrane
  • Postsynaptic Density
  • Lamellipodium
  • Dendritic Spine Head
  • Postsynaptic Membrane
  • Phagocytic Vesicle
Molecular Function
  • GTPase Activator Activity
  • Protein Binding
  • Small GTPase Binding
  • Identical Protein Binding
  • Protein Homodimerization Activity
Biological Process
  • Lamellipodium Assembly Involved In Ameboidal Cell Migration
  • Signal Transduction
  • Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration
  • Negative Regulation Of Cell Migration
  • Substrate Adhesion-dependent Cell Spreading
  • Positive Regulation Of GTPase Activity
  • Filopodium Assembly
  • Neuron Projection Morphogenesis
  • Actin Filament Severing
  • Regulation Of Small GTPase Mediated Signal Transduction
  • Negative Regulation Of Cell Death
  • Dendritic Spine Development
  • Negative Regulation Of Neuron Migration
Pathways
  • Rho GTPase cycle
  • Inactivation of CDC42 and RAC1
  • RHO GTPases Activate Formins
Drugs
Diseases
GWAS
  • Asthma ( 32296059)
  • Cholesterol and Triglycerides ( 23031429)
  • Refractive error ( 32231278)
  • Type 2 diabetes ( 30297969)
Interacting Genes 5 interacting genes: DISC1 EXOC1 FASLG ROBO1 YWHAG
Entrez ID 23380
HPRD ID 18520
Ensembl ID ENSG00000266028
Uniprot IDs A0A075B7B5 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs 2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025