PROK2 and TMBIM1

Data Source:
BioGRID (two hybrid)

		PROK2	TMBIM1
Description		prokineticin 2	transmembrane BAX inhibitor motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Lysosomal Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding	Death Receptor Binding Protein Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Endothelial Cell Proliferation Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Spermatogenesis Circadian Rhythm Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Contraction	Negative Regulation Of Catalytic Activity Neutrophil Degranulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Neutrophil degranulation
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Blood protein levels ( 30072576) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Serum metabolite levels (CMS) ( 31636271)	Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Red cell distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		1 interacting genes: TMBIM1	13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63
Entrez ID		60675	64114
HPRD ID		08446	17884
Ensembl ID		ENSG00000163421	ENSG00000135926
Uniprot IDs		Q9HC23	A0A024R472 B3KSM0 B4DUD2 Q969X1
PDB IDs
Enriched GO Terms of Interacting Partners?
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