TMBIM1 and RIC3

Data Source:
BioGRID (two hybrid)

		TMBIM1	RIC3
Description		transmembrane BAX inhibitor motif containing 1	RIC3 acetylcholine receptor chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	Death Receptor Binding Protein Binding	Acetylcholine Receptor Binding Protein Folding Chaperone
	Biological Process	Negative Regulation Of Catalytic Activity Neutrophil Degranulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling	Protein Folding Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission, Cholinergic Protein Localization To Cell Surface Cellular Protein-containing Complex Assembly
Pathways		Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Red cell distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Malaria ( 31844061)
Interacting Genes		13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63	15 interacting genes: BCL2L1 CLN6 FA2H FATE1 GOSR2 NINJ2 PRB1 STX12 STX7 TMBIM1 TMEFF2 TMEM11 TMEM86A TRAF3IP3 YIF1A
Entrez ID		64114	79608
HPRD ID		17884	17974
Ensembl ID		ENSG00000135926	ENSG00000166405
Uniprot IDs		A0A024R472 B3KSM0 B4DUD2 Q969X1	A0A0S2Z607 A0A0S2Z6D3 B7Z3Z0 D3DQU6 Q7Z5B4
PDB IDs
Enriched GO Terms of Interacting Partners?
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