RIC8A and GNAI1

Data Source:
HPRD (in vitro, two hybrid)

		RIC8A	GNAI1
Description		RIC8 guanine nucleotide exchange factor A	G protein subunit alpha i1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding
	Biological Process	In Utero Embryonic Development Vasculature Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Visual Learning Cell Migration Involved In Gastrulation Positive Regulation Of GTPase Activity Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex
Pathways			PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs			Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		24 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 NECAB2 NUTM1 PACSIN2 RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		60626	2770
HPRD ID		12373	00756
Ensembl ID		ENSG00000177963	ENSG00000127955
Uniprot IDs		Q9NPQ8	P63096
PDB IDs			1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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