EDA2R and AGR3

Data Source:
BioGRID (two hybrid)

		EDA2R	AGR3
Description		ectodysplasin A2 receptor	anterior gradient 3, protein disulphide isomerase family member
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Intracellular Membrane-bounded Organelle
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Signaling Receptor Activity	Dystroglycan Binding Protein Binding
	Biological Process	Multicellular Organism Development Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Biological_process Negative Regulation Of Cell Death
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Balding ( 26926045) Male-pattern baldness ( 27182965 22032556 28196072)	Coffee consumption ( 31959922 29367735) Cutaneous malignant melanoma ( 32341527 26237428) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		16 interacting genes: AGR3 ATP6V0C C1QB CASP8 CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 TMEM262 TRAF3 TRAF6	35 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2
Entrez ID		60401	155465
HPRD ID		02230	16545
Ensembl ID		ENSG00000131080	ENSG00000173467
Uniprot IDs		B2RBZ9 B4DQY6 Q9HAV5	Q8TD06
PDB IDs			3PH9
Enriched GO Terms of Interacting Partners?
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