RLN2 and RXFP2

Data Source:
HPRD (in vitro)

		RLN2	RXFP2
Description		relaxin 2	relaxin family peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity	G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Female Pregnancy Positive Regulation Of Gene Expression Positive Regulation Of Angiogenesis Regulation Of Catalytic Activity	Oocyte Maturation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling
Pathways		G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases			46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS			Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: RXFP1 RXFP2	2 interacting genes: INSL3 RLN2
Entrez ID		6019	122042
HPRD ID		01561	05976
Ensembl ID		ENSG00000107014	ENSG00000133105
Uniprot IDs		P04090	Q8WXD0
PDB IDs		2MV1 6RLX	2M96
Enriched GO Terms of Interacting Partners?
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