RXFP2 and RLN2

Data Source:
HPRD (in vitro)

		RXFP2	RLN2
Description		relaxin family peptide receptor 2	relaxin 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region
	Molecular Function	G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding	Hormone Activity
	Biological Process	Oocyte Maturation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling	G Protein-coupled Receptor Signaling Pathway Female Pregnancy Positive Regulation Of Gene Expression Positive Regulation Of Angiogenesis Regulation Of Catalytic Activity
Pathways		G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: INSL3 RLN2	2 interacting genes: RXFP1 RXFP2
Entrez ID		122042	6019
HPRD ID		05976	01561
Ensembl ID		ENSG00000133105	ENSG00000107014
Uniprot IDs		Q8WXD0	P04090
PDB IDs		2M96	2MV1 6RLX
Enriched GO Terms of Interacting Partners?
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