RLF and FBXL17

Data Source:
BioGRID (two hybrid)

		RLF	FBXL17
Description		RLF zinc finger	F-box and leucine rich repeat protein 17
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)
Interacting Genes		7 interacting genes: CLK1 FBXL17 GCH1 PRPF40A RIT1 RIT2 TRIM14	42 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 USP25 ZMYM2 ZNF350
Entrez ID		6018	64839
HPRD ID		01614	10950
Ensembl ID		ENSG00000117000	ENSG00000145743
Uniprot IDs		Q13129	Q9UF56
PDB IDs			6W66 6WCQ
Enriched GO Terms of Interacting Partners?
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