RLF and PPT1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		RLF	PPT1
Description		RLF zinc finger	palmitoyl-protein thioesterase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Nucleus Lysosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Lysosomal Lumen Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Protein Binding Palmitoyl-(protein) Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Thiolester Hydrolase Activity Lysophosphatidic Acid Binding Sulfatide Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	Protein Depalmitoylation Receptor-mediated Endocytosis Pinocytosis Lysosomal Lumen Acidification Nervous System Development Brain Development Visual Perception Protein Transport Lipid Catabolic Process Protein Phosphopantetheinylation Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity Response To Stimulus
Pathways			Fatty acyl-CoA biosynthesis
Drugs			Hexadecanesulfonyl fluoride Palmitic Acid
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Blood protein levels ( 30072576 29875488) Platelet count ( 32888494)
Interacting Genes		7 interacting genes: CLK1 FBXL17 GCH1 PRPF40A RIT1 RIT2 TRIM14	1 interacting genes: GNAQ
Entrez ID		6018	5538
HPRD ID		01614	07203
Ensembl ID		ENSG00000117000	ENSG00000131238
Uniprot IDs		Q13129	P50897
PDB IDs			3GRO
Enriched GO Terms of Interacting Partners?
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