PPT1

Description		palmitoyl-protein thioesterase 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Lysosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Lysosomal Lumen Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Thiolester Hydrolase Activity Lysophosphatidic Acid Binding Sulfatide Binding
	Biological Process	Protein Depalmitoylation Receptor-mediated Endocytosis Pinocytosis Lysosomal Lumen Acidification Nervous System Development Brain Development Visual Perception Protein Transport Lipid Catabolic Process Protein Phosphopantetheinylation Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity Response To Stimulus
Pathways		Fatty acyl-CoA biosynthesis
Drugs		Hexadecanesulfonyl fluoride Palmitic Acid
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576 29875488) Platelet count ( 32888494)
Novel Interacting Genes		3 novel interacting genes: COL6A3 EPS15 RLF
Interacting Genes		1 interacting genes: GNAQ
Entrez ID		5538
HPRD ID		07203
Ensembl ID		ENSG00000131238
Uniprot IDs		P50897
PDB IDs		3GRO
Enriched GO Terms of Interacting Partners?
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