RLBP1 and NR2F2

Data Source:
HPRD (in vitro)

		RLBP1	NR2F2
Description		retinaldehyde binding protein 1	nuclear receptor subfamily 2 group F member 2
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GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell Body	Nucleus Nucleoplasm Cytosol
	Molecular Function	11-cis Retinal Binding Protein Binding Retinol Binding Phosphatidylinositol Bisphosphate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Retinoid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Anatomical Structure Development Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment
Pathways		The retinoid cycle in cones (daylight vision) The retinoid cycle in cones (daylight vision) Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Newfoundland rod-cone dystrophy (NFRCD) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 28813576) Age-related macular degeneration (SNP x mitochondrial G12771A interaction) ( 28813576) Schizophrenia ( 28991256)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		4 interacting genes: APP KLHL8 RDH5 SLC9A3R1	18 interacting genes: BCL11A BCL11B BIK EP300 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TENT5A TRIM24 TRIP4
Entrez ID		6017	7026
HPRD ID		01572	00139
Ensembl ID		ENSG00000140522	ENSG00000185551
Uniprot IDs		P12271	F1D8R0 P24468
PDB IDs		1XGG 1XGH 3HX3 3HY5 4CIZ 4CJ6	3CJW
Enriched GO Terms of Interacting Partners?
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