GRM5 and PRKCA

Data Source:
HPRD (in vitro)

		GRM5	PRKCA
Description		glutamate metabotropic receptor 5	protein kinase C alpha
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Membrane Alphav-beta3 Integrin-PKCalpha Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Translation Regulation Of Translational Elongation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Long-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Protein Tyrosine Kinase Activity Modulation Of Age-related Behavioral Decline Postsynaptic Modulation Of Chemical Synaptic Transmission Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Intracellular Calcium Activated Chloride Channel Activity Cellular Response To Amyloid-beta	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Acamprosate ADX10059 Rufinamide Dipraglurant	Phosphatidyl serine Vitamin E Tamoxifen Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)	Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 30012220 27659466) QT interval ( 29213071 24952745 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)
Interacting Genes		19 interacting genes: ACTN1 CALM1 CALM2 CALM3 EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN	228 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SLC9A3R1 SLC9A3R2 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		2915	5578
HPRD ID		04980	01498
Ensembl ID		ENSG00000168959	ENSG00000154229
Uniprot IDs		A8K5P7 P41594	L7RSM7 P17252 Q7Z727
PDB IDs		3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52	2ELI 3IW4 4DNL 4RA4
Enriched GO Terms of Interacting Partners?
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