GNAI3 and HTR1A

Data Source:
HPRD (in vitro, in vivo)

		GNAI3	HTR1A
Description		G protein subunit alpha i3	5-hydroxytryptamine receptor 1A
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction
	Biological Process	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Serotonin receptors
Drugs			Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856
Diseases
GWAS		Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)	Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		2773	3350
HPRD ID		00765	00190
Ensembl ID		ENSG00000065135	ENSG00000178394
Uniprot IDs		P08754	A8K5W4 P08908 Q5ZGX3
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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