REST and SUB1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		REST	SUB1
Description		RE1 silencing transcription factor	SUB1 regulator of transcription
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Hypoxia Response To Ischemia Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Somatic Stem Cell Population Maintenance Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Neuronal Stem Cell Population Maintenance Modification Of Synaptic Structure Positive Regulation Of Stem Cell Population Maintenance Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA Metabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter SMAD Protein Signal Transduction
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 21909106) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 25429064 31562340) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Migraine ( 27322543) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 29403010) Plateletcrit ( 32888494) Response to bleomycin (chromatid breaks) ( 21106707) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) White blood cell count ( 32888494)	Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		10 interacting genes: AURKA CDYL GTF2B HTT MAPK1 PLK1 RCOR1 SIN3B SUB1 TBP	22 interacting genes: ADAP1 APP CBX5 CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 OTUD5 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST SDCBP SP1 TAF1 TBP TP53
Entrez ID		5978	10923
HPRD ID		08990	02737
Ensembl ID		ENSG00000084093	ENSG00000113387
Uniprot IDs		A0A1W2PQA1 Q13127	P53999 Q6IBA2
PDB IDs		2CZY 6DU2 6DU3	1PCF 2C62 2PHE 4USG 6YCS
Enriched GO Terms of Interacting Partners?
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