SIGIRR and IL1R1

Data Source:
HPRD (in vivo)

		SIGIRR	IL1R1
Description		single Ig and TIR domain containing	interleukin 1 receptor type 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS
Drugs			Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		59307	3554
HPRD ID		12018	00994
Ensembl ID		ENSG00000185187	ENSG00000115594
Uniprot IDs		C9JFX4 Q6IA17	B8ZZW4 P14778
PDB IDs			1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?
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