SIGIRR and ENO2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SIGIRR	ENO2
Description		single Ig and TIR domain containing	enolase 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Membrane Perikaryon Extracellular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus	Gluconeogenesis Glycolytic Process Regulation Of Vacuole Fusion, Non-autophagic Canonical Glycolysis
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	Glycolysis Gluconeogenesis
Drugs			2-Phosphoglycolic Acid
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	25 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C
Entrez ID		59307	2026
HPRD ID		12018	00573
Ensembl ID		ENSG00000185187	ENSG00000111674
Uniprot IDs		C9JFX4 Q6IA17	P09104 Q6FHV6
PDB IDs			1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ
Enriched GO Terms of Interacting Partners?
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