RBBP5 and CHD8

Data Source:
BioGRID (two hybrid)

		RBBP5	CHD8
Description		RB binding protein 5, histone lysine methyltransferase complex subunit	chromodomain helicase DNA binding protein 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific)	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Response To Estrogen Post-translational Protein Modification Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Mean platelet volume ( 24026423 32888494) Meat-related diet ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Height ( 31562340)
Interacting Genes		13 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 PTEN RB1 UBE2I WDR5	11 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 SUMO2 TOP3B WDR5
Entrez ID		5929	57680
HPRD ID		02826	16712
Ensembl ID		ENSG00000117222	ENSG00000100888
Uniprot IDs		A0A024R9B5 B4DLF8 Q15291	Q9HCK8
PDB IDs		3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7 6PWV 6PWW 6PWX 7BRE	2CKA 2DL6
Enriched GO Terms of Interacting Partners?
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