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CHD8 and ASH2L
Data Source:
BioGRID
(two hybrid)
CHD8
ASH2L
Description
chromodomain helicase DNA binding protein 8
ASH2 like, histone lysine methyltransferase complex subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Protein-containing Complex
MLL1 Complex
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
MLL3/4 Complex
Set1C/COMPASS Complex
Molecular Function
P53 Binding
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Beta-catenin Binding
DNA-dependent ATPase Activity
Methylated Histone Binding
Histone Binding
Armadillo Repeat Domain Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Beta-catenin Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Brain Development
Wnt Signaling Pathway
DNA Duplex Unwinding
Social Behavior
ATP-dependent Chromatin Remodeling
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Digestive Tract Development
Prepulse Inhibition
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Fibroblast Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Hemopoiesis
Response To Estrogen
Regulation Of Megakaryocyte Differentiation
Histone H3-K4 Methylation
Beta-catenin-TCF Complex Assembly
Pathways
Deactivation of the beta-catenin transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PKMTs methylate histone lysines
Deactivation of the beta-catenin transactivating complex
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS
Height (
31562340
)
Menopause (age at onset) (
22267201
)
Schizophrenia (
29483656
)
Interacting Genes
11 interacting genes:
AR
ASH2L
CHD7
CREB1
CTCF
CTNNB1
RBBP5
RCHY1
SUMO2
TOP3B
WDR5
37 interacting genes:
ACTC1
ACTN2
ANKRD1
BARD1
BRCA1
CCNC
CEP76
CHD8
COPS6
CTNNB1
DNMT3L
DPY30
EP300
H3-4
H3C1
KMT2A
KMT2B
KMT2D
KMT2E
MEN1
MESD
MKRN1
MYBPC1
MYOM3
PPP1CC
PRMT1
RBBP5
SMAD9
SMURF1
SMURF2
TGFBR1
TP53
TTN
UNC119
WDR5
WWP1
ZSCAN1
Entrez ID
57680
9070
HPRD ID
16712
05309
Ensembl ID
ENSG00000100888
ENSG00000129691
Uniprot IDs
Q9HCK8
B4DPT1
F5H8F7
Q9UBL3
PDB IDs
2CKA
2DL6
3RSN
3S32
3TOJ
4RIQ
4X8N
4X8P
5F6K
5F6L
6E2H
6KIU
6KIV
6KIW
6KIX
6KIZ
6PWV
7BRE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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