HIVEP3 and TNFRSF1B

Data Source:
HPRD (in vivo)

		HIVEP3	TNFRSF1B
Description		HIVEP zinc finger 3	TNF receptor superfamily member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process
Pathways		Regulation of RUNX2 expression and activity	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Tasonermin
Diseases			Graft-versus-host disease
GWAS		Adult body size ( 32376654) Airway imaging phenotypes ( 26030696) Breast cancer ( 29059683) Bronchopulmonary dysplasia ( 23897914) Diastolic blood pressure ( 27618452) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) Heel bone mineral density ( 30598549) High myopia ( 32428537) Intraocular pressure ( 29235454) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spatial memory ( 31596458) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 27618452 30578418) Treatment resistant depression ( 30468137) White blood cell count ( 32888494)	Asthma ( 31959851) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		5 interacting genes: FHL1 RUNX2 TNFRSF1B TRAF1 TRAF2	21 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		59269	7133
HPRD ID		09442	01862
Ensembl ID		ENSG00000127124	ENSG00000028137
Uniprot IDs		Q5T1R4	P20333
PDB IDs			1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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