ARID4A and BRMS1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		ARID4A	BRMS1
Description		AT-rich interaction domain 4A	BRMS1 transcriptional repressor and anoikis regulator
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Transcription Repressor Complex	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Spermatogenesis Histone H4-K20 Trimethylation Histone H3-K9 Trimethylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Histone H3-K4 Trimethylation Establishment Of Sertoli Cell Barrier	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption in current drinkers ( 28937693) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Problematic alcohol use ( 32451486) Venous thromboembolism ( 31420334) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		15 interacting genes: BRMS1 CCNA2 CCNB1 CCND1 CCNE1 CDK1 CDK2 CDK4 EID1 H3C14 H4-16 HDAC1 HDAC2 HDAC3 SIN3A	49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1
Entrez ID		5926	25855
HPRD ID		01575	05879
Ensembl ID		ENSG00000032219	ENSG00000174744
Uniprot IDs		A0A024R657 A0A024R680 A0A024R6A2 P29374 Q05CG0	G5E9I4 Q9HCU9
PDB IDs		2LCC 2MAM 2YRV 6BPH	2XUS 4AUV
Enriched GO Terms of Interacting Partners?
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