RARS1 and ZNF521

Data Source:
BioGRID (two hybrid)

		RARS1	ZNF521
Description		arginyl-tRNA synthetase 1	zinc finger protein 521
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome	Nucleus
	Molecular Function	TRNA Binding Arginine-tRNA Ligase Activity Protein Binding ATP Binding Arginine Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Chronotype ( 30696823) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Height ( 31562340) High density lipoprotein cholesterol levels ( 30498476) Mitochondrial DNA levels ( 25240745) Myeloproliferative neoplasms ( 33057200) Nickel levels ( 26025379) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Systemic juvenile idiopathic arthritis ( 27927641) Takayasu arteritis ( 25604533) Toenail selenium levels ( 25343990) Urgency urinary incontinence ( 25524241)
Interacting Genes		77 interacting genes: AIMP1 CCDC115 CDC42 EPRS1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I QARS1 SUMO2 ZNF521	8 interacting genes: BRAP EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4
Entrez ID		5917	25925
HPRD ID		00142	18350
Ensembl ID		ENSG00000113643	ENSG00000198795
Uniprot IDs		P54136	J3KTI4 Q8IYZ2 Q96K83
PDB IDs		4Q2T 4Q2X 4Q2Y 4R3Z 4ZAJ
Enriched GO Terms of Interacting Partners?
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