RAB27B and MLPH

Data Source:
HPRD (in vivo)

		RAB27B	MLPH
Description		RAB27B, member RAS oncogene family	melanophilin
Image			No pdb structure
GO Annotations	Cellular Component	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm	Dendrite Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Actin Binding Protein Binding Myosin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Intracellular Protein Transport Melanosome Transport
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Central corneal thickness ( 32528159) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Prostate cancer ( 21743057)
Interacting Genes		11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D	7 interacting genes: BLOC1S6 C1orf216 MTDH MYO5A RAB27A RAB27B RECK
Entrez ID		5874	79083
HPRD ID		04846	09409
Ensembl ID		ENSG00000041353	ENSG00000115648
Uniprot IDs		O00194	A0A024R4D3 Q9BV36
PDB IDs		2F7S
Enriched GO Terms of Interacting Partners?
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