MLPH and MYO5A

Data Source:
HPRD (in vitro, in vivo)

		MLPH	MYO5A
Description		melanophilin	myosin VA
Image		No pdb structure
GO Annotations	Cellular Component	Dendrite Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Myosin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Metal Ion Binding	Microfilament Motor Activity RNA Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Small GTPase Binding Actin Filament Binding
	Biological Process	Intracellular Protein Transport Melanosome Transport	Post-Golgi Vesicle-mediated Transport Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Central corneal thickness ( 32528159) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Prostate cancer ( 21743057)	Mean platelet volume ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		7 interacting genes: BLOC1S6 C1orf216 MTDH MYO5A RAB27A RAB27B RECK	17 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 KIF5B MLPH NDEL1 NEFL PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3
Entrez ID		79083	4644
HPRD ID		09409	01179
Ensembl ID		ENSG00000115648	ENSG00000197535
Uniprot IDs		A0A024R4D3 Q9BV36	A8CDT9 Q9UES4 Q9Y4I1
PDB IDs			4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?
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